natural + minimal ingredients
Fluoride-free · 10% hydroxyapatite

Introducing ONE+

Brush with what teeth are made of.

10% nano and micro hydroxyapatite — the mineral your enamel is already made of. Two particle-size ranges for maximum results.

Ingredients
16
nHAp + mHAp
10%
No decay-index
89%
new fluoride-free toothpaste Best overall 2026 · Exact-Net →
20 reviews

One+

fluoride-free, natural, hydroxyapatite toothpaste

  • Made with the mineral teeth are made of
  • Supports enamel remineralization
  • 10% nano + micro hydroxyapatite
  • No SLS · no artificial dyes · fluoride-free

How you'd like it

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60-day guarantee
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Full ingredient list — 16

Water, Sorbitol, Glycerin, Potassium Sorbate, Hydroxyapatite (nano & micro), Xylitol, Sodium Cocoyl Glutamate, Cellulose Gum, Xanthan Gum, Zinc Citrate, Aloe Vera, Mentha Piperita (Peppermint) Oil, Mentha Viridis (Spearmint) Leaf Oil, Menthol, Sodium Benzoate, Stevia Rebaudiana Leaf/Stem Extract.

How to use

Use a pea-sized amount on a soft-bristle brush for two minutes, morning and night. Spit — don't rinse — so a light mineral film stays on the teeth. For children under 3 use a rice-grain amount; ages 3–6 use a pea-sized amount with supervision.

Product facts

Paste. 120 g · 4.23 oz per tube, approximately 90 brushings. pH 7.4 ± 0.2. Abrasivity RDA 62 — low. Fluoride 0 ppm. SLS-free, no artificial dyes. Developed and fulfilled in Utah, USA.

Shipping & returns

In-stock orders are processed in 1–2 business days, excluding weekends and holidays. Carrier transit time is additional. Eligible U.S. orders of $20 or more after discounts qualify for free standard shipping. Contact us within 60 days for help under our satisfaction guarantee; see the refund policy for terms.

How the subscription works

One tube a month at the subscriber price. Skip a month, push the date back, swap pack size, or cancel from your account. No skip fees and no phone call.

89%

of adults using a 10% hydroxyapatite toothpaste had no increase in the study’s decay index over 18 months. The formula was non-inferior to 1450 ppm fluoride for that endpoint. The study tested a different formula, not Klyyr One+.

View the study →
Klyyr oral care lifestyle — Abstract motion-blur photograph of colorful wildflowers in soft light

03 — What is Klyyr?

Three / Chapters

What is klyyr?

Fully listed ingredients.

Sixteen ingredients, each named and explained. No SLS, no artificial dyes, and nothing hidden behind a catch-all flavor label.

  • 16 ingredients
  • Fully listed
Klyyr hydroxyapatite toothpaste story — Fresh mint plant photographed against a light studio background

Clear intentions.

We built Klyyr for people who read labels: clearly disclosed 10% nano + micro hydroxyapatite in a fully listed 16-ingredient formula.

  • 10% nHAp
  • Fluoride-free
Klyyr hydroxyapatite toothpaste story — Extreme close-up of a bright, healthy smile with glossy lips

Clear lifestyle.

Morning counter, not medicine cabinet. The tube belongs next to the towel and the coffee — part of a routine that doesn't need a lecture.

  • Daily use
  • Peppermint + spearmint
Klyyr hydroxyapatite toothpaste story — Lone tree in a wildflower meadow at dusk under a pink and blue sky

04 — The science

What the evidence says

In an 18-month adult study, 10% HAp performed as well as fluoride.
Evidence Peer-reviewed
Scope Ingredient-level
Important Different formulas

Results that speak for themselves.

Published studies help explain why hydroxyapatite is used in oral care. The research below evaluated other toothpaste formulations or laboratory models—not Klyyr One+. We cite the exact result, study type, and limitations so ingredient-level evidence is not mistaken for a Klyyr clinical claim.

Summary In an 18-month adult trial, 89.3% of the hydroxyapatite group and 87.4% of the fluoride group had no increase in the study's DMFS endpoint. The hydroxyapatite toothpaste was non-inferior for the primary endpoint. The trial tested a different formula, not Klyyr.

Sources https://pmc.ncbi.nlm.nih.gov/articles/PMC10393266/

Summary Nine of ten participants in the study's hydroxyapatite arm showed a sensitivity response over two to four weeks. The arm was small and used a different toothpaste, so this is context—not a prediction of individual results.

Sources https://pmc.ncbi.nlm.nih.gov/articles/PMC9022388/

Summary A laboratory experiment measured 92.6% stain-removal efficacy after 180 seconds for another commercial hydroxyapatite toothpaste. This was an in-vitro comparison, not a Klyyr clinical result.

Sources https://pmc.ncbi.nlm.nih.gov/articles/PMC12025712/

06 — Hydroxyapatite Ca₁₀(PO₄)₆(OH)₂

Interactive particle visualization of a tooth formed from hydroxyapatite mineral particles.

The mineral

The mineral, explained.

Hydroxyapatite is a calcium phosphate mineral closely related to enamel and dentin. Published studies have examined it in toothpastes for remineralization, sensitivity, stain removal, and caries—results depend on the formula. One+ uses 10% nano and micro hydroxyapatite, with both particle sizes and every other ingredient listed.

Biocompatible Fluoride alternative Clinically studied Nano + micro
01 How does hydroxyapatite compare with fluoride?

Hydroxyapatite is a fluoride-free alternative with growing clinical evidence. In one 18-month adult study, a 10% HAp toothpaste was non-inferior to 1450 ppm fluoride for the study's primary caries endpoint. That study tested a different formula, so it is ingredient-level evidence—not a Klyyr clinical result. Read the hydroxyapatite vs fluoride comparison.

02 Why nano and micro hydroxyapatite?

Nano and micro refer to particle-size ranges. Published ingredient research examines how smaller particles interact with microscopic defects and dentinal tubules, while larger particles remain closer to the tooth surface. One+ includes both at a combined 10% concentration. Read nano vs micro hydroxyapatite toothpaste.

03 Can children use it?

For children under 3, use a rice-grain amount; for ages 3–6, use a pea-sized amount. A caregiver should supervise brushing and encourage children to spit rather than intentionally swallow. Ask your child's dentist about individual needs, especially when switching from fluoride. See hydroxyapatite toothpaste for kids.

04 Can I use it during pregnancy?

All 16 ingredients are disclosed so you can review them with your dentist or OB. Pregnancy can change oral-health needs, so ask your care team before making a material change to your routine.

05 What's the actual ingredient list?

Water, Sorbitol, Glycerin, Potassium Sorbate, Hydroxyapatite (nano & micro), Xylitol, Sodium Cocoyl Glutamate, Cellulose Gum, Xanthan Gum, Zinc Citrate, Aloe Vera, Mentha Piperita (Peppermint) Oil, Mentha Viridis (Spearmint) Leaf Oil, Menthol, Sodium Benzoate, Stevia Rebaudiana Leaf/Stem Extract. That's the whole thing. Paste any toothpaste list into the toothpaste ingredient checker.

06 How does the subscription work?

Choose an available delivery schedule and the current selling-plan savings will be shown before checkout. Skip, pause, or cancel from your account. Shipping cost and eligibility are confirmed at checkout.

07 Is the tube recyclable?

The tube body is aluminum and the cap is HDPE. Rinse and separate the components, then recycle each one where accepted locally.

08 Why does it cost more than some drugstore toothpastes?

One+ contains a clearly disclosed 10% nano + micro hydroxyapatite blend, comes in a 120 g aluminum tube, and lists all 16 ingredients. Current one-time and subscription prices are shown before checkout.

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09 — Independent research

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